Spicy Southern Chicken Spaghetti Casserole is a hearty, comforting dish full of tender chicken, spaghetti noodles, and a spicy kick that warms you up from the inside out. Creamy cheese and a blend of southern spices come together to create a cozy, flavorful meal that’s both filling and exciting. This casserole is a wonderful twist on classic southern cooking with just the right bit of heat to keep things interesting.
I love making this casserole when I want something easy to prepare but still packed with flavor. It’s one of those recipes that lets me use simple ingredients but get a tasty, satisfying dinner on the table quickly. One tip I like to follow is to let it sit for a few minutes after baking so the flavors can really settle. The spicy notes become even more balanced, and the cheesy top crisps up just right.
This dish is perfect for family dinners or potlucks because it feeds a crowd and everyone always asks for seconds. I usually serve it alongside a fresh green salad or some steamed veggies to add a lighter touch to the rich casserole. It’s one I always come back to when I want a bit of a southern flavor boost with a nice little spicy edge.
Key Ingredients & Substitutions
Spaghetti: Regular spaghetti works great here, but you can also try whole wheat or gluten-free pasta if you want a different texture or need a gluten-free option.
Chicken: Shredded cooked chicken is key for texture and flavor. Rotisserie chicken is a helpful shortcut, but baked or grilled chicken breast shredded at home works well too.
Cheese: Sharp cheddar adds strong flavor while Monterey Jack melts smoothly for creaminess. If you want a milder dish, swap sharp cheddar for mild cheddar or Colby cheese.
Creamy Base: The combo of cream of mushroom soup, sour cream, and mayo creates a rich sauce. For a lighter version, you can use Greek yogurt instead of mayo or sour cream.
Spices: Cajun seasoning brings the southern heat. If you avoid spice, reduce it or omit cayenne pepper. Smoked paprika adds a subtle smoky note that makes the dish stand out.
How Can I Make This Casserole Creamy Without It Being Watery?
Getting a creamy casserole without watery or soggy noodles is always a challenge. Here are some tips I use:
- Cook spaghetti just until al dente. Overcooked pasta will absorb too much sauce and get mushy.
- Drain pasta well and avoid rinsing it. The starch helps sauce stick.
- Mix the sauce ingredients (mushroom soup, sour cream, mayo, milk) thoroughly before combining with pasta to ensure even coating.
- Don’t add extra liquid beyond the recipe—it can make the casserole watery during baking.
- After baking, let the casserole rest 5-10 minutes so the sauce thickens and sets nicely.
Equipment You’ll Need
- Large pot – for boiling the spaghetti; roomy enough to prevent sticking.
- Skillet or frying pan – perfect for sautéing onions, garlic, and chicken with your spices.
- Large mixing bowl – helps you mix the creamy sauce, pasta, and chicken evenly.
- 9×13-inch baking dish – spacious enough to hold the casserole and bake it evenly.
- Wooden spoon or spatula – great for stirring without scratching your cookware.
- Colander – to drain the pasta quickly and easily.
Flavor Variations & Add-Ins
- Swap chicken for cooked and crumbled spicy sausage to add smoky, rich flavor.
- Add diced bell peppers or jalapeños for extra crunch and heat.
- Mix in cooked spinach or kale to boost freshness and color.
- Try pepper jack cheese instead of Monterey Jack for a bit more spice and creaminess.
Spicy Southern Chicken Spaghetti Casserole
Ingredients You’ll Need:
- 8 oz spaghetti
- 2 cups cooked chicken breast, shredded
- 1 cup cherry tomatoes, halved
- 1 cup shredded sharp cheddar cheese
- 1 cup shredded Monterey Jack cheese
- 1 can (10.5 oz) cream of mushroom soup
- 1 cup sour cream
- ½ cup mayonnaise
- ½ cup milk
- 2 cloves garlic, minced
- 1 medium onion, finely chopped
- 1-2 tsp Cajun seasoning (adjust to taste)
- ½ tsp smoked paprika
- ¼ tsp cayenne pepper (optional)
- 2 tbsp olive oil or butter
- Salt and pepper, to taste
- Fresh parsley or green onions for garnish (optional)
Time Needed:
Preparation and cooking together take about 45 minutes, including boiling the pasta, sautéing ingredients, assembling the casserole, and baking. You’ll want a few extra minutes after baking for the casserole to rest and the flavors to settle.
Step-by-Step Instructions:
1. Preheat and Prepare Pasta:
Start by preheating your oven to 350°F (175°C). Cook the spaghetti according to the package until al dente, then drain well and set aside.
2. Make the Chicken and Spice Mix:
Heat olive oil or butter in a skillet over medium heat. Sauté the chopped onion until translucent, about 3-4 minutes. Add minced garlic, cooking for another minute until fragrant. Stir in shredded chicken, Cajun seasoning, smoked paprika, cayenne pepper if using, salt, and pepper. Cook for 2-3 minutes, stirring so the spices blend well.
3. Mix the Creamy Sauce and Combine:
In a large bowl, combine cream of mushroom soup, sour cream, mayonnaise, and milk. Stir until creamy and smooth. Add the cooked spaghetti, chicken mixture, and half of the shredded cheeses. Mix until everything is coated evenly.
4. Assemble and Bake:
Transfer the pasta mixture to a greased 9×13-inch baking dish. Spread the cherry tomato halves evenly on top, then sprinkle with the remaining shredded cheese. Bake uncovered for 25-30 minutes until the cheese melts and turns bubbly and golden.
5. Let Rest and Serve:
After baking, let the casserole rest for 5-10 minutes so it sets nicely. Garnish with fresh parsley or green onions if you like, then serve warm. Enjoy your delicious Spicy Southern Chicken Spaghetti Casserole!
Can I Use Frozen Chicken for This Casserole?
Yes! Just be sure to thaw it completely before shredding and using. The best way is to thaw frozen chicken overnight in the fridge. If you’re in a hurry, you can use the defrost setting on your microwave, but cook it immediately after thawing.
What Can I Substitute for Cream of Mushroom Soup?
If you prefer not to use canned soup, you can make a quick homemade creamy sauce with butter, flour, and milk or broth. Simply melt 2 tablespoons of butter, stir in 2 tablespoons flour to form a roux, then whisk in 1 cup milk or broth until thickened. Season with salt and pepper.
How Do I Store Leftovers?
Store leftover casserole in an airtight container in the fridge for up to 3 days. Reheat individual portions in the microwave or warm the whole casserole in the oven at 350°F until heated through.
Can I Make This Casserole Ahead of Time?
Absolutely! Prepare the casserole up to the baking step, then cover and refrigerate for up to 24 hours. When ready, bake as directed, adding a few extra minutes if baking straight from the fridge.
